molecular genetic laboratories

Most molecular genetic laboratories will test for the
commonest CF mutations using either an ARMS (amplification
refractory mutation system) PCR analysis or other
mutation-specific tests such as OLA (oligonucleotide ligation
assay). It should be remembered that since the frequency of
mutations varies between populations, the panel of mutations
tested in one ethnic group may be of less value in another
ethnic group and consequently knowledge of the mutation
spectrum in the local population is important.